The substance derived from this plant material contains various volatile organic compounds, among which the alkaloid nicotine is the most pharmacologically active. Chemically, the combustion process generates a complex mixture of toxins, including carbon monoxide, acetaldehyde, and various nitrosamines. Biologically, the primary harmful effects are attributed to the neurotoxicity of nicotine, which acts as an agonist at nicotinic acetylcholine receptors, leading to systemic stimulation. Furthermore, the particulate matter and associated chemicals irritate the respiratory system and promote chronic inflammatory responses in pulmonary tissues.