Personal protective equipment (PPE) refers to a range of devices, clothing, and physical barriers used by individuals to minimize exposure to hazards in operational or occupational settings. These items are designed to prevent contact with potential sources of harm, such as biological agents, hazardous chemicals, particulate matter, or physical trauma. The efficacy of PPE relies on material science and engineering principles, providing filtration, shielding, or physical separation between the wearer and the surrounding environment. Proper selection, fit, and use of PPE are critical components of standard biosafety and industrial safety protocols.