Gout

Gout is a type of inflammatory arthritis caused by hyperuricemia, which involves elevated levels of uric acid in the bloodstream. This excess uric acid can lead to the precipitation of sharp crystals, specifically monosodium urate, within the synovial fluid of joints. When these crystals accumulate, they trigger an acute inflammatory response, resulting in episodes of intense pain, marked swelling, and redness in the affected joints, with the metatarsophalangeal joint of the big toe being a common site. Management strategies focus on lowering the serum concentration of uric acid through dietary modifications that reduce purine intake, as well as through pharmacological treatments designed to prevent crystal formation and mitigate inflammatory episodes.