Gangrene is a form of tissue death resulting from an inadequate blood supply, a condition known as ischemia, or from associated bacterial infection. It represents necrosis of the affected tissue, which can range in severity from mild discoloration to full-scale tissue demise. The condition often develops following severe trauma, circulatory failure, or uncontrolled metabolic disease. Clinical presentations vary depending on the underlying cause, with subtypes including dry gangrene, which typically involves desiccation and shriveling of the affected area, and wet gangrene, which involves tissue death coupled with bacterial proliferation and liquefaction. Because the necrotic tissue provides a favorable environment for infection, management often requires surgical intervention, such as debridement, to remove the dead tissue and prevent systemic spread of infection.